Type 2 diabetes: Drugs initially increase glucose production

Although SGLT-2 inhibitors are central to the treatment of diabetes, their exact mode of action was hitherto unknown. In a study conducted by a research group led by Peter Wolf, Martin Krssak and Michael Krebs from MedUni Vienna’s Department of Medicine III, magnetic resonance spectroscopy (MRS) was used to show that there is a direct correlation between the elimination of glucose via the kidneys and new glucose production in the liver. A single dose of the SGLT-2 inhibitor dapagliflozin gives rise to a beneficial regulation mechanism, in which glucose loss due to drug-induced SGLT-2 inhibition is exactly balanced out by an equal increase in new glucose production in the liver. The study has been published in the leading journal Diabetes Care.

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