- Eating too much damaged omega-6 fat and too little animal-based omega-3 sets the stage for diabetes, cardiovascular disease, rheumatoid arthritis, cancer, depression, Alzheimer’s and more
- Research shows replacing saturated fat with omega-6 oils raises your risk of death if you have heart disease
- Omega-6 fat in and of itself is not the problem. Linoleic acid is also found in foods such as nuts, seeds and eggs, and is important for health. The problem is that we now eat far too much of it, and in oxidized form
- Omega-6 linoleic acid reduces omega-3 in your body by competing with the omega-3 ALA for metabolism to the longer chained PUFAs, EPA and DHA
- Oxidation of LDL cholesterol is initiated by the oxidation of the linoleic acid inside the LDL particles, and oxidized LDL is associated with the development of atherosclerosis
Dietary fats can be tricky business, as they’re not all the same. While some are necessary for optimal health, others need to be balanced and some need to be avoided altogether, and understanding which is which is quite crucial, considering how important fats are for optimal health.
Here, I will review some of the basics, including the importance of balancing your omega-3 and omega-6 intake, and why replacing saturated animal fats with omega-6-rich vegetable oils is such a bad idea.
Some of this information, which will be more thoroughly covered in my upcoming book, “Superfuel,” is based on research by my coauthor, James DiNicolantonio, a doctor of pharmacy and cardiovascular researcher.
For Optimal Health, Mind Your Omega-3 to Omega-6 Ratio
For years, I’ve stressed the importance of balancing your omega-3 to omega-6 intake to protect your health. Eating too much damaged omega-6 fat — found in abundance in processed vegetable oils — and too little animal-based omega-3 sets the stage for diabetes, cardiovascular disease, rheumatoid arthritis, cancer, depression and Alzheimer’s, just to name a few.
The ideal ratio of omega-3 to omega-6 fats ranges from 1-to-1 to 1-to-5, but the typical Western diet tends to be between 1-to-20 and 1-to-50. Most people, especially Americans, are guilty of this lopsided omega-3 to omega-6 ratio, and to correct it, you typically need to do two things:
1. Significantly decrease intake of damaged omega-6 by avoiding processed foods and foods cooked in vegetable oil at high temperatures. A number of studies1,2 have found that people who regularly eat deep-fried foods have a significantly increased risk of stroke and death.
Common sources of harmful omega-6 to avoid include corn oil, canola oil, soy oil, hydrogenated or partially hydrogenated fats, margarine and shortening.
2. Increase your intake of animal-based omega-3 fats. Ideal sources include small fatty fish such as sardines, anchovies and herring, along with wild-caught Alaskan salmon, or a supplement such as krill oil.
Replacing Saturated Fats With Vegetable Oils Harms Heart Health
Unfortunately, many health authorities have insisted omega-6-rich vegetable oils are healthier than saturated animal fats such as butter and lard, and this myth has been a tough one to dismantle, despite the evidence against it.
For example, a 2013 study3 in the British Medical Journal (BMJ) found replacing saturated fat with omega-6 oils raised the risk of death if you have heart disease. As reported in a BMJ press release:4
“Their analysis involved 458 men aged 30 to 59 years who had recently had a coronary event, such as a heart attack or an episode of angina. Participants were randomly divided into two groups.
The intervention group was instructed to reduce saturated fats (from animal fats, common margarines and shortenings) to less than 10 percent of energy intake and to increase linoleic acid (from safflower oil and safflower oil polyunsaturated margarine) to 15 percent of energy intake. Safflower oil is a concentrated source of omega-6 linoleic acid and provides no omega-3 PUFAs [polyunsaturated fats].”
The control group received no specific dietary advice on fats and was allowed to eat whatever they wanted. Both groups kept food diaries for an average of 39 months.
It’s worth noting that this study did not differentiate between types of saturated fats, lumping together animal fats with margarines and shortening high in saturated fat but also toxic trans fats. (The harder the margarine, the more saturated fat it tends to contain, in some cases more than butter or lard.) Despite this discrepancy, the results showed that:
- The omega-6 linoleic acid group had a 17 percent higher risk of dying from heart disease during the study period, compared with 11 percent among the control group
- The omega-6 group also had a higher risk of all-cause mortality
Omega-6 Oils Do Not Provide Cardiovascular Benefit
The researchers also conducted a meta-analysis of linoleic acid intervention trials, finding no evidence of cardiovascular benefit. According to the authors, “These findings could have important implications for worldwide dietary advice to substitute omega-6 linoleic acid, or PUFAs in general, for saturated fats.”
Jane Collis, an independent researcher not affiliated with the research also commented on the BMJ study, saying:5
“Commercial food processing destroys a significant amount of EFAs [essential fatty acids], along with their oxygenating ability … Polyunsaturated oils are unstable and very quickly become rancid.
Oxidized fatty acids are dangerous to your health. Lipid peroxidation and oxidative stress are important factors in this damage. Further damage is also caused by heating polyunsaturated fats in cooking (particularly frying foods).
Many omega-3 research trials did not consider the omega 3/6 essential fatty acid ratio which is vital to the eicossanoid balance. The correct omega 3/6 ratio is fundamental to holistic health for all.”
Oxidized Omega-6 Fat Is a Primary Driver of Heart Disease
Next, let’s take a look at why omega-6 industrially processed vegetable oils promote heart disease. First of all, it’s important to recognize that omega-6 fat in and of itself is not the problem. Linoleic acid is also found in foods such as nuts, seeds and eggs, and is important for health.
In a groundbreaking new publication entitled “Omega-6 Vegetable Oils as a Driver of Coronary Heart Disease: The Oxidized Linoleic Acid Hypothesis,”6 published in BMJ Open Heart by DiNicolantonio, he explains the following:
The problem is that we now eat far too much omega-6, which creates a severe imbalance in the omega-3 to omega-6 ratio. Today, omega-6 PUFAs make up around 8 to 10 percent of the total energy intake in the Western world. This is largely related to the large amounts of processed foods consumed that are loaded with these dangerous fats.
What’s worse, the primary source of omega-6 is no longer eggs and nuts but rather processed vegetable oils, and most of this linoleic acid is oxidized from the processing.
In the early 1900s, consumption of vegetable oils skyrocketed, taking the place of butter and lard, and so did incidence of heart disease. Evidence implicating excessive consumption of omega-6-rich vegetable oils as a direct cause of heart disease include but is not limited to:
- The amount of linoleic acid in adipose tissue and platelets is positively associated with coronary artery disease, and studies7 measuring changes in linoleic acid concentrations in adipose tissue in Americans show concentrations increased from 9.1 percent in 1959 to 21.5 percent in 2008. This increase also paralleled increases in the prevalence of obesity, diabetes and asthma.
- Conversely, the long-chained omega-3s docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) have been shown to protect against coronary artery disease, which is why maintaining a healthy balance between omega-3 and omega-6 is so important.
- Patients with atherosclerosis have higher amounts of linoleic acid oxidation products in their plasma, low-density lipoprotein (LDL) and atherosclerotic plaques.
- Oxidation of linoleic acid begins before any clinical signs of atherosclerosis become apparent.
- When the endothelium (the interior lining of your blood vessels) is exposed to linoleic acid, LDL transfer across the endothelium is increased and this is an essential step in the atherosclerotic process.
- Low linoleic acid diets reduce LDL oxidation.
- A meta-analysis of randomized controlled trials in humans showed that when saturated fat and trans fat are replaced with omega-6 PUFAs, all-cause mortality, ischemic heart disease mortality and cardiovascular mortality increase.
- Oxidation products of linoleic acid are found in infarcted tissue.
- The linoleic acid metabolite 9-HODE is a strong promoter of inflammation, and may be both a marker for and inducer of atherosclerosis.
Omega-6 May Reduce Omega-3 in Your Body
You can obtain omega-3 fats from both plants and marine animals like fish and krill. However, these sources provide different types of omega-3, and they are not interchangeable. Plant-based omega-3 contains alpha-linolenic acid (ALA), a shorter-chained omega 3 fat.
ALA is a precursor to the longer-chained omega 3 fats EPA and DHA. However, an enzyme is required for its conversion, and in most people, this enzyme doesn’t work very well. Hence the conversion rate is exceptionally small. Typically, less than 1 percent of the ALA is converted to EPA. Some studies have found the conversion rate to be as 0.1 to 0.5 percent.8
Your conversion is also dependent on having adequate levels of other vitamins and minerals. So, while a tiny amount of the ALA you consume can be converted by your body into long-chain omega-3, it’s a highly inefficient strategy and nowhere near as helpful as supplying “straight” DHA and EPA from marine sources.
Getting back to omega-6, linoleic acid actually reduces omega-3 in your body by competing with the ALA for metabolism to the longer chained EPA and DHA. This information is particularly relevant for vegans and vegetarians who often make the mistake of thinking their body will convert plant-based ALA to EPA and DHA.
Not only is it near-impossible to get sufficient amounts of EPA and DHA this way, but whatever minor conversion may theoretically take place is further hindered if you’re consuming excessive amounts of omega-6 from vegetable oils and processed foods.
LDL Oxidation Is Initiated by Oxidation of Linoleic Acid
Ample research suggests heart disease is caused not by elevated total cholesterol but, rather, by oxidized LDLs. Unoxidized LDL, even when elevated, does not contribute to atherosclerosis. But what causes LDL oxidation?
Studies9 have shown LDL oxidation is actually triggered or initiated by the oxidation of the linoleic acid inside the LDL particles. As noted by DiNicolantonio in “Omega-6 Vegetable Oils as a Driver of Coronary Heart Disease: The Oxidized Linoleic Acid Hypothesis:”
“Once linoleic acid becomes oxidized in LDL aldehydes and ketones covalently bind apoB, creating LDL that is no longer recognized by the LDL receptors in the liver but is now recognized by scavenger receptors on macrophages leading to the classic foam cell formation and atherosclerosis.10,11,12
Hence, the amount of linoleic acid contained in LDL can be seen as the true ‘culprit’ that initiates the process of oxidized LDL formation as it is the linoleic acid that is highly susceptible to oxidation.
Additionally, an increase in the intake of linoleic acid intake increases the linoleic acid content of very-low density lipoprotein (VLDL) and high-density lipoprotein (HDL) increasing their susceptibility to oxidize, which further increases the risk of cardiovascular disease.13,14,15
Thus, expanding on the oxidized LDL theory of heart disease, a more comprehensive theory, the ‘oxidized linoleic acid theory of coronary heart disease’ is as follows:
Dietary linoleic acid, especially when consumed from refined omega-6 vegetable oils, gets incorporated into all blood lipoproteins (such as LDL, VLDL and HDL) increasing the susceptibility of all lipoproteins to oxidize and hence increases cardiovascular risk.”16
Saturated Fat Protects Against Oxidation of Cholesterol Whereas Omega-6 Promotes It
Oxidized cholesterol has also been implicated in atherosclerosis. This hypothesis is what led to the demonization of dietary cholesterol and saturated fat. Alas, when cholesterol is bound to saturated fat, oxidation does not readily occur. Linoleic acid, on the other hand, does promote oxidation of cholesterol.
In fact, plaques taken from patients with atherosclerosis have been found to contain cholesteryl linoleate — i.e., cholesterol esters that contain linoleic acid — and higher oxidized cholesteryl linoleate levels also correlate with atherosclerosis severity.
In short, when cholesterol is bound to saturated fat, it is protected from oxidation, which lowers your risk for cardiovascular disease, and when it is bound to linoleic acid, the cholesterol is susceptible to oxidation, thereby raising your risk. Linoleic acid also increases your risk of heart disease by reducing high-density lipoprotein (HDL) cholesterol.17,18 As noted by DiNicolantonio:
“Numerous lines of evidence show that the omega-6 polyunsaturated fat linoleic acid promotes oxidative stress, oxidized LDL, chronic low-grade inflammation, atherosclerosis, and is likely a major dietary culprit for causing coronary heart disease, especially when consumed in the form of industrial seed oils commonly referred to as ‘vegetable oils.”
Understanding Dietary Fats Is Important for Optimal Health
When it comes to cooking foods with oil, one of the things to watch for is oils that are hydrogenated or interesterified (a fat where the triglyceride molecule is engineered to change the melting point of the oil). Organic, grass fed butter is among the best fats to cook with.
Ghee, another delicious alternative, has been used for cooking for eons and is another good choice, as is organic unrefined coconut oil. Among the worst are vegetable oils high in omega-6 linolenic acid, which include corn oils, soybean oil, safflower, cottonseed and canola oils.
Anupam Ghose, a physician by training, was diagnosed with Type 2 Diabetes Mellitus (T2DM) in 2017. After the diagnosis of T2DM, he followed a low carbohydrate high fat (ketogenic) diet and reversed his T2DM within a year. Now he is on a mission to educate people and spread awareness about T2DM. Since he could reverse his T2DM following a ketogenic diet, now he is performing extensive research on ketogenic diet and expanding his knowledge on this particular topic. His main goal is to make people understand that the conventional method of treating T2DM is not very helpful and it is possible to reverse T2DM through diet and lifestyle modification.