Scientists establish novel 'Kuma mutant' mouse model of permanent neonatal diabetes



Diabetes seldom occurs in newborns—a condition known as neonatal diabetes. But when it does, it’s mostly due to a mutation in a single gene such as the KCNJ11 or insulin (INS). This early-onset type of diabetes differs from type-1 diabetes in that it occurs within the first six months of life and can be either transient or permanent. Most of the mutations that underly this disease prevent the pancreas from producing sufficient insulin, which leads to high blood glucose levels or hyperglycemia.



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