Deleting a liver enzyme lowers the health risk of sweet treats (at least in mice)



Excessive sugar and fat in the diet can lead to hepatic (liver) insulin resistance. Often seen in people who are obese, hepatic insulin resistance leads to unhealthy levels of fatty lipids in the liver and is a risk factor for serious illnesses like type 2 diabetes and cardiovascular disease. Researchers at the University of Tsukuba are attempting to unravel the complicated physiology of insulin resistance, and in a new study published in Hepatology, they show how one gene can have a major impact on insulin resistance in the liver.



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