Metformin is a common type 2 diabetes drug. Recently, it was found to extend life span of young non-diabetic animals but the responses of older organisms to metformin remain unexplored. Researchers at the Leibniz Institute on Aging—Fritz Lipmann Institute (FLI) in Jena, Germany, and the Friedrich Schiller University Jena found that mitochondrial dysfunction abrogates metformin benefits in aged C. elegans and late passage human cells. Moreover, the same metformin regime that prolongs the lifespan of young nematodes was toxic in old animals by inducing deleterious metabolic changes. These findings suggest that aging sets a limit for the health span benefits of metformin outside of diabetes.
Anupam Ghose, a physician by training, was diagnosed with Type 2 Diabetes Mellitus (T2DM) in 2017. After the diagnosis of T2DM, he followed a low carbohydrate high fat diet and reversed his T2DM within a year. Now he has one main goal in life and that is to make people understand that the conventional method of treating T2DM is not beneficial. Type 2 diabetes is reversible and the best way to reverse T2DM is through diet and lifestyle modifications. He now decided to help people with type 2 diabetes by offering online coaching to reverse their diabetes.