A gatekeeper against insulin resistance in the brain



The brain plays a major role in controlling our blood glucose levels. In type 2 diabetics this glucose metabolism brain control is often dysfunctional. Genetic components for this phenomenon have so far remained elusive. A group of scientists at Helmholtz Zentrum M√ľnchen and the German Center for Diabetes Research (DZD) have now shown in the Journal of Clinical Investigations that in men a genetic variant of the gene DUSP8 can increase the risk for type 2 diabetes by impairing our brain response to the hormone insulin.



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